2F-Ketamine Review

2F-ketamine is a synthetic substance derived from ketamine, which is commonly used medically and recreationally as an anesthetic. 2F-ketamine, however, is primarily used as a recreational research chemical and does not currently hold approval for applications in medicine.

This article contains a 2-FDCK research chemical review and gives an overview of general information, history, dosage & administration information, other user reviews, and potential side effects.

General Information on 2F-Ketamine

2F-ketamine is classified as a type of dissociative anesthetic and shares a similar molecular structure with ketamine. It’s also commonly referred to as its true name, 2-fluorodeschloroketamine, or abbreviated as 2-FDCK.

2-FDCK is widely available in both powder and crystal forms, though availability of either may vary between suppliers. It’s typically off-white or yellowish in color. Though less common, it may also be found in pill or capsule form. Users may also personally encapsulate it.

2-Flurorodeschoroketamine is detectable in both blood and urinalysis, but typically isn’t included in most testing panels and often has to be tested using specific testing that has to be performed separately from standard 5- or 10-panel tests.

History of 2F-Ketamine

2-FDCK is relatively new among legal highs and was initially developed as an anesthetic alternative to ketamine for medical use, though both ketamine and 2F-ketamine are also widely used for recreational purposes. The first written record of this research chemical appeared in 2013, and it became available online through various distributors around 2017. Its predecessor, ketamine, was first created in the early 1960s, allowing recreational users several decades of experience before 2-FDCK was introduced.

2F-ketamine is illegal in many countries–including Japan, Italy, Sweden, and Switzerland, among others. Several countries like Canada and the United Kingdom have enacted umbrella laws to prohibit the manufacture, distribution, and possession of 2F-ketamine without specifically naming the research chemical in the legislation. This is also true of some states in the US, so always check your local ordinances to ensure that 2-FDCK is a legal high in your area, as it varies from state to state and possibly from county to county.

2F-ketamine is available online through research chemical distributors. It is also distributed by individuals in various regions.

Dosage and Administration

Substance use, even with legal drugs like 2F-Ketamine, should be approached cautiously with an understanding of all risks and benefits involved.

The effects of 2-FDCK can differ based on:

  • the dosage amount and frequency
  • the user’s health, height, and weight
  • the user’s previous experience with the substance
  • additional substances used at the same time, including prescription medications
  • the method of administration
  • the user’s tolerance of this or similar substances

When administering any substance, use a test kit or strips to ensure the legitimacy of the drug and follow harm reduction protocols like sober supervision for the best outcome.

It’s recommended to start with a small dose initially and then increase the dosage as you become more familiar with the effects and the way your body reacts to 2-FDCK.

20-50mg per 100 lbs. of body weight is a typical dose for administration via the following methods:

Oral Administration

2-fluorodeschloroketamine can be swallowed in pill or capsule form, mixed with a drinking liquid and ingested, or wrapped in rolling paper and swallowed in a process called “bombing”. This is the most common method of administration.

Nasal Insufflation

2-FDCK can be insufflated nasally (also commonly referred to as “snorting”) to speed up the onset of the effects. This method is often reported to be mildly to intensely uncomfortable and may cause pain or a burning sensation in the nasal passages.

Suppository Administration

Some users prefer to encapsulate or dissolve 2-FDCK and insert it into the rectum as a suppository. This method of administration typically doesn’t alter the effects of the substance and often results in a more rapid onset of effect compared to oral administration.


Users often report administering subsequent doses to prolong the effects of 2-FDCK. When redosing, aim to use an equal or lesser amount than the initial dose until you know how the drug reacts in your system. If you’re experiencing negative side effects, it’s not recommended to redose. A common side effect of 2-FDCK is a compulsion to redose, so use caution when determining whether or not to continue administration.

User 2F-Ketamine Reviews

Research chemical reviews, including this 2F-ketamine review, are often self-reported and should be taken anecdotally, not as evidence or fact. The timelines and effects mentioned here are an approximation based on the self-reported experience of other users.

Onset of Effects

Depending on the method of administration, expect effects to set in anywhere from 20-40 minutes. The onset of effects seems to differ depending on the method of administration, as it may set in more gradually or more rapidly depending on how it’s administered.

Increased Creativity

Some users report feeling more creative and more inclined toward imaginative thinking and creative pursuits under the influence of 2F-ketamine.

Decreased Pain

Because 2-fluorodeschloroketamine was developed for use as an anesthetic, many users experience physical pain relief while using it. The degree of relief varies depending on the type and severity of the user’s pain.


Many users experience mild to intense feelings of euphoria as a result of administering 2-FDCK. This can also sometimes be experienced as an overwhelming feeling of warmth, happiness, or satisfaction.

Intense Dreams

Users often report experiencing intense, vivid dreams during or immediately after using 2F-ketamine. These dreams are often reported to be out of the ordinary for the typical user and may be uncomfortable for some.


As the effects of the substance wear off, users may experience drowsiness and low mood. These effects are temporary and may wear off within 1-2 hours of the beginning of the offset. Experience during the comedown may vary by user.

Potential Side Effects of 2F-Ketamine

As with any substance, there are potential side effects of 2-FDCK. Some of the potential side effects include (but aren’t limited to):

  • Dizziness and disorientation
  • Loss of motor coordination
  • Hyperventilation
  • Hyperthermia
  • Hypertension
  • Nausea and vomiting
  • Increased perspiration
  • Depersonalization
  • Dissociation
  • Paranoia
  • Psychosis
  • Chest pain
  • Seizures
  • Amnesia and time distortion
  • Impaired cognitive function
  • Incontinence and bloody urine
  • Hallucinations
  • Death

If you experience severe negative effects, contact your local emergency department and let them know the dosage and frequency of 2F-Ketamine that you have self-administered to prevent reactions with other drugs they may prescribe to prevent further harm.

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